Inflammation is a natural immune response that helps protect the body from infection, injury, and environmental stressors. However, prolonged or chronic inflammation has been associated with various health conditions, including cardiovascular issues, metabolic concerns, and neurodegenerative disorders.[1]

Research published by Epax suggests that omega-3 fatty acids may support the body’s inflammatory balance. Omega-3 fatty acids (EPA and DHA) are believed to play a role in modulating this response.[1]

“Increasing dietary intake of marine Omega-3s may be a practical approach to supporting a healthy inflammatory response.” — Epax Scientific Review on Inflammation.[1]

How Omega-3s Influence Inflammation at the Cellular Level

Omega-3s, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have been widely studied for their ability to influence inflammation at the molecular level. These fatty acids are integrated into cell membranes, where they play several key roles:

• Modulating Cell Membrane Flexibility: DHA influences the structure and function of cell membranes, making them less reactive to pro-inflammatory signals.[1]  
• Influences the Impact of Inflammatory Signals: EPA influences the production of pro-inflammatory molecules and promoting pro-resolving lipid mediators known as resolvins.[1] 
• Supporting the Body’s Ability to Regulate Inflammation: Once an immune response is no longer needed, omega-3s help regulate the resolution phase, preventing excessive inflammation from damaging tissues.[1] 

“Omega-3 fatty acids are often referred to as ‘anti-inflammatory’ fatty acids, though the mechanism is more about balancing the inflammatory response rather than eliminating it.” — OmegaQuant Study on Inflammation.[2]

Omega-3s and Chronic Inflammation: What the Research Shows

Numerous studies have explored the relationship between omega-3 levels and inflammation-related conditions:

• Cardiovascular Health: Clinical trials suggest that consuming 3-4 grams of EPA/DHA daily may help support healthy blood triglyceride levels, blood pressure, and vascular flexibility, factors linked to cardiovascular health.[1]
• Brain & Neurological Health: Research indicates that chronic inflammation may play a role in overall health. Some studies suggest that higher plasma DHA levels correlate with better cognitive function and a lower likelihood of cognitive decline.[1]
• Immune and Joint Support: Studies suggest that omega 3s may help support both joints and immune system.1]
• The Omega-3 Index and Inflammation: The Framingham Cohort Study, a large-scale longitudinal study, found an association between higher Omega-3 Index levels and lower inflammatory markers, suggesting a potential role for omega-3 intake in inflammation management.[2]

“The higher the Omega-3 Index, the lower the inflammatory markers.” — Framingham Study on Inflammation and Omega-3s.[2]

Why Adequate Omega-3 Intake Matters

One of the biggest nutritional concerns today is insufficient intake of omega-3 fatty acids in the modern diet. Research suggests that inadequate omega-3 intake may contribute to a pro-inflammatory state.[1] The typical Western diet tends to be low in omega-3 fatty acids, which are found in sources like fatty fish. Some studies indicate that increasing EPA/DHA intake through diet and supplementation may help support a healthy inflammatory response.[1]

Choosing the Right Omega-3 Supplement for a Balanced Response 

Research indicates that marine-based omega-3s from fish oil may be among the most bioavailable sources for increasing Omega-3 Index scores and supporting immune function.[1]

When selecting an omega-3 supplement, key factors to consider include:

• EPA & DHA Content – Essential for cellular function and omega-3 balance.
• Bioavailability – Triglyceride-form fish oil has been studied for its absorption efficiency.
• Full-Spectrum Omega Support – Additional omega forms (7, 9, 11) may provide complementary benefits
• Sustainability & Purity – Sourced for purity and low contaminant levels.

Yoli’s Mission: Supporting Omega-3 Research and Awareness

Despite extensive research on omega-3’s role in overall wellness, studies indicate that many individuals have an Omega-3 Index below 8%, a level associated with an increased risk of cardiovascular, cognitive, and metabolic concerns.[2]

Yoli aims to address this by offering resources focused on education, testing, and supplementation. Through a science-backed approach, individuals can make informed decisions about their omega-3 intake.

• Testing Omega-3 Levels – Advanced Omega-3 Index testing allows individuals to assess baseline levels and track changes over time. Yoli customers have seen significant improvements in their Omega-3 Index levels. For example, some have experienced increases from below 4% to over 10%, while others have moved from the mid-8% range to nearly 12%. 
• Educational Initiatives – Yoli promotes awareness about the importance of maintaining balanced omega-3 levels.
• Full-Spectrum Omega Supplementation – Yoli’s Vital Omegas line provides EPA, DHA, and additional omegas (3, 7, 9, 11) for a broader nutritional profile.

“Yoli is not just providing omega supplements—we’re providing a complete system for testing, education, and optimization, helping more people reach an Omega-3 Index of 8% or higher.”  – Corey Citron, Yoli Founder

By integrating testing, education, and supplementation, Yoli contributes to ongoing efforts in omega-3 research and awareness.

1. Williams EJ, Baines KJ, Smart JM, Gibson PG, Wood LG. Rosuvastatin, Lycopene and Omega-3 fatty acids: A potential treatment for systemic inflammation in COPD; a pilot study. J of Nutr & Intermediary Metabolism. 2016;5:86-95
2. Harris WS, Del Gobbo L, Tintle NL. The Omega-3 Index and Inflammation: Results from the Framingham Study. OmegaQuant; 2015. Available at: https://omegaquant.com/omega-3-index-inflammation-results-framingham-study/

Disclaimer: The claims made about these products have not been reviewed by the Food and Drug Administration, and their effectiveness has not been verified through FDA-approved studies. These products are not intended to diagnose, treat, cure, or prevent any disease. The information provided is not intended to replace advice from healthcare providers. Always consult with your healthcare professional regarding possible interactions or other concerns before using any product. Testimonials in this article reflect personal experiences and are not guaranteed. Results may vary based on individual effort, experience, and commitment. Use your judgment when considering any product.

Published by Elle G.